Histological Analysis of Intestinum Tenue Rabbit Atherosclerosis Model

Atherosclerosis is a vascular disease that occurs as result of progressive inflammatory response in blood vessels. The method inducing atherosclerosis with the rabbit animal model can be done by modifying high-fat diet which lead to hypercholesterolemia within few days inducement atheromatic lesions. This study was conducted analyze histology small intestine group rabbits fed standard and atherogenic diet. results morphometry analysis showed duodenal submucosa B wider than A, while length jejunal villi shorter A. Changes were also followed changes cell population. number goblet cells duodenum less compared but jejunum actually more Further research needed determine mechanism causes this change so it support modeling according pathophysiology pathogenesis diseases occur humans.